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Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (AA 235-263)

Details for Product anti-CASP6 Antibody No. ABIN388106, Supplier: Login to see
Antigen
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 235-263, C-Term
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40
34
23
17
15
13
13
11
6
6
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5
5
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4
3
3
2
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2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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1
Reactivity
Human, Mouse (Murine)
284
82
78
15
3
2
Host
Rabbit
280
19
19
Clonality (Clone)
Polyclonal ()
Conjugate
This Caspase 6 antibody is un-conjugated
19
18
14
11
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4
3
3
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Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
262
154
109
56
35
26
25
16
9
6
5
5
1
Supplier
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Immunogen This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 AA from the C-terminal region of human CASP6.
Clone RB06896
Isotype Ig
Specificity This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CASP6.
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP6 (CASP6 Antibody Abstract)
Background CASP6 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein could be processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade.
Synonyms: Caspase-6, CASP-6, Apoptotic protease Mch-2, CASP6, MCH2,
Molecular Weight 33310 DA
Gene ID 839
UniProt P55212
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (AA 235-263) (ABIN388106) Western blot analysis of anti-CASP6 Antibody (C-term) (ABIN388106) in mouse liver tis...
Immunohistochemistry (IHC) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (AA 235-263) (ABIN388106) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CASP6 ...
Background publications Sordet, Rébé, Dubrez-Daloz et al.: "Intracellular redistribution of procaspases during TPA-induced differentiation of U937 human leukemic cells." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 16, Issue 8, pp. 1569-70, 2002 (PubMed).

MacLachlan, El-Deiry: "Apoptotic threshold is lowered by p53 transactivation of caspase-6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 14, pp. 9492-7, 2002 (PubMed).

LeBlanc, Liu, Goodyer et al.: "Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 274, Issue 33, pp. 23426-36, 1999 (PubMed).