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Details for Product No. ABIN388127

HtrA Serine Peptidase 1 (HTRA1) (N-Term), (AA 116-147) antibody

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Antigen
Synonyms ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, HTRA, Prss11, RSPP11, AI429470, Xhtra1, htra, prss11, htra1, zgc:92029, zgc:172061, l56, MGC145723
Epitope
»Alternatives N-Term, AA 116-147
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN388127
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-147 AA from the N-terminal region of human HtrA1.
Clone RB02326
Isotype Ig
Specificity This HtrA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124~153 amino acids from the N-terminal region of human HtrA1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HtrA1
Background HtrA1 a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth.
Synonyms: Serine protease HTRA1, L56
Molecular Weight 51286 DA
Gene ID 5654
UniProt Q92743
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Zumbrunn, Trueb: "Localization of the gene for a serine protease with IGF-binding domain (PRSS11) to human chromosome 10q25.3-q26.2." in: Genomics, Vol. 45, Issue 2, pp. 461-2, 1998 (PubMed).

Hu, Carozza, Klein et al.: "Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34406-12, 1999 (PubMed).

Chien, Staub, Hu et al.: "A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer." in: Oncogene, Vol. 23, Issue 8, pp. 1636-44, 2004 (PubMed).

Howes, Lerch, Greenhalf et al.: "Clinical and genetic characteristics of hereditary pancreatitis in Europe." in: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Vol. 2, Issue 3, pp. 252-61, 2004 (PubMed).

Alternatives for antigen "HtrA Serine Peptidase 1 (HTRA1)", type "Antibodies"
Hosts (21)
Reactivities (21), (7), (4), (2), (2), (1), (1)
Applications (21), (10), (6), (5), (4), (4), (2)
Conjugates (2)
Epitopes (5), (4), (3), (2), (1), (1)
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