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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term), (AA 5-35) antibody

Details for Product No. ABIN388140
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Antigen
Epitope
N-Term, AA 5-35
(26), (19), (9), (7), (7), (7), (2), (2), (1), (1)
Reactivity
Human
(87), (2), (1)
Host
Rabbit
(67), (16), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(85), (58), (34), (20), (2), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN388140
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This CEM15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-35 AA from the N-terminal region of human CEM15.
Clone RB01736
Isotype Ig
Specificity This CEM15 antibody is generated from mice immunized with KLH conjugated synthetic peptides corresponding to N-terminal of human CEM15.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CEM15
Background CEM15 is a member of the cytidine deaminase family. It is the product of one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. CEM15 has been found to be a specific inhibitor of human immunodeficiency virus-1 (HIV-1) infectivity.
Synonyms: DNA dC->dU-editing enzyme APOBEC-3G, APOBEC-related cytidine deaminase, ARCD, APOBEC-related protein, ARP-9, CEM15, CEM-15, APOBEC3G, MDS019
Molecular Weight 46408 DA
Gene ID 60489
Research Area Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term), (AA 5-35) antibody The anti-CEM15 N-term Pab (ABIN388140) is used in Western blot to detect CEM15 in HL60 cell lysate.
anti-Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3G (APOBEC3G) (N-Term), (AA 5-35) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Wedekind, Dance, Sowden et al.: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, 2003 (PubMed).

Zhang, Yang, Pomerantz et al.: "The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA." in: Nature, Vol. 424, Issue 6944, pp. 94-8, 2003 (PubMed).

Mangeat, Turelli, Caron et al.: "Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts." in: Nature, Vol. 424, Issue 6944, pp. 99-103, 2003 (PubMed).

Stopak, de Noronha, Yonemoto et al.: "HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability." in: Molecular cell, Vol. 12, Issue 3, pp. 591-601, 2003 (PubMed).

Kao, Khan, Miyagi et al.: "The human immunodeficiency virus type 1 Vif protein reduces intracellular expression and inhibits packaging of APOBEC3G (CEM15), a cellular inhibitor of virus infectivity." in: Journal of virology, Vol. 77, Issue 21, pp. 11398-407, 2003 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN388140
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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