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alpha Fetoprotein antibody (alpha-Fetoprotein) (AA 300-329)

Details for Product anti-AFP Antibody No. ABIN388199, Supplier: Log in to see
Antigen
  • FETA
  • HPAFP
Epitope
AA 300-329, Center
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11
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2
2
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Reactivity
Human
716
62
47
22
20
7
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5
3
2
1
Host
Rabbit
437
281
43
9
6
2
Clonality (Clone)
Polyclonal ()
Conjugate
This alpha Fetoprotein antibody is un-conjugated
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34
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4
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3
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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307
136
116
52
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42
36
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28
22
9
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2
1
1
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1
Supplier
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Immunogen This AFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 AA from the Central region of human AFP.
Clone RB13358
Isotype Ig
Specificity This AFP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307~337 amino acids from the Center region of human AFP.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AFP (alpha 1 Fetoprotein) (AFP Antibody Abstract)
Background Alpha-fetoprotein (AFP) is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Synonyms: Alpha-fetoprotein, Alpha-fetoglobulin, Alpha-1-fetoprotein, AFP, HPAFP
Molecular Weight 68678 DA
Gene ID 174
UniProt P02771
Research Area Stem Cells, Transcription Factors, Signaling, Chromatin
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-alpha Fetoprotein antibody (alpha-Fetoprotein) (AA 300-329) (ABIN388199) Western blot analysis of AFP (arrow) using rabbit polyclonal AFP Antibody (Center) (A...
Immunohistochemistry (IHC) image for anti-alpha Fetoprotein antibody (alpha-Fetoprotein) (AA 300-329) (ABIN388199) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with AFP an...
Background publications Yamashita, Forgues, Wang et al.: "EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 5, pp. 1451-61, 2008 (PubMed).

Cajaiba, Sarita-Reyes, Zambrano et al.: "Mesenchymal hamartoma of the liver associated with features of Beckwith-Wiedemann syndrome and high serum alpha-fetoprotein levels." in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, Vol. 10, Issue 3, pp. 233-8, 2007 (PubMed).