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SPRED1 antibody (Sprouty-Related, EVH1 Domain Containing 1) (AA 44-73)

Details for Product anti-SPRED1 Antibody No. ABIN388231, Supplier: Log in to see
Antigen
  • 5730461F13Rik
  • AL024345
  • AW047647
  • fb14c08
  • fj51c03
  • hSpred1
  • NFLS
  • spred-1
  • wu:fb14c08
  • wu:fj51c03
  • Xspred1
  • Xtspred1
  • zgc:85707
Epitope
AA 44-73, N-Term
18
17
14
14
5
4
2
2
1
1
1
1
Reactivity
Human
110
17
11
Host
Rabbit
75
35
Clonality (Clone)
Polyclonal ()
Conjugate
This SPRED1 antibody is un-conjugated
8
8
8
8
7
7
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
102
77
39
16
13
4
2
1
Supplier
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Immunogen This SPRED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 AA from the N-terminal region of human SPRED1.
Clone RB13254
Isotype Ig
Specificity This SPRED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~81 amino acids from the N-terminal region of human SPRED1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SPRED1 (SPRED1 Antibody Abstract)
Background SPRED1 is a tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
Synonyms: Sprouty-related, EVH1 domain-containing protein 1, Spred-1, SPRED1,
Molecular Weight 50477 DA
Gene ID 161742
UniProt Q7Z699
Research Area Stem Cells, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SPRED1 antibody (Sprouty-Related, EVH1 Domain Containing 1) (AA 44-73) (ABIN388231) Western blot analysis of SPRED1 (arrow) using rabbit polyclonal SPRED1 Antibody (N-te...
Immunohistochemistry (IHC) image for anti-SPRED1 antibody (Sprouty-Related, EVH1 Domain Containing 1) (AA 44-73) (ABIN388231) Formalin-fixed and paraffin-embedded human brain tissue reacted with SPRED1 antibody ...
Background publications Brems, Chmara, Sahbatou, Denayer, Taniguchi, Kato, Somers, Messiaen, De Schepper, Fryns, Cools, Marynen, Thomas, Yoshimura, Legius: "Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype." in: Nature genetics, Vol. 39, Issue 9, pp. 1120-6, 2007

Yoshida, Hisamoto, Akiba, Koga, Nakamura, Tokunaga, Hanada, Kumemura, Maeyama, Harada, Ogata, Yano, Kojiro, Ueno, Yoshimura, Sata: "Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors." in: Oncogene, Vol. 25, Issue 45, pp. 6056-66, 2006