Sorting Nexin 6 (SNX6) (Center) antibody

Antigen: Sorting Nexin 6 (SNX6)

Synonyms: TFAF2, MGC3157, MSTP010, C85963, AU018928, 2010006G21Rik, 2610032J07Rik, 2810425K19Rik, MGC75952, MGC80251, MGC110798, im:7146294, zgc:110798, DKFZp459M2127

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN388256

Additional Information

Alternative name: SNX6

Gene ID: 58533

UniProt: Q9UNH7

Immunogen: This SNX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267~296 amino acids from the Center region of human SNX6.

Isotype: Ig

Description: Other names: TRAF4-associated factor 2, Sorting nexin-6

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This SNX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267~296 amino acids from the Center region of human SNX6.

Molecular Weight: 46649 DA

Comments:

Background: SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor p

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Stem Cells, Cell Cycle, Cell Structure

Restrictions: For Research Use only

Images

Western blot analysis of SNX6 Antibody (Center) (ABIN388256) in SK-BR-3 cell line lysates (35ug/lane). SNX6(arrow) was detected using the purified Pab (1:60 dilution).

Publications

Product: Parks, Frank, Huff et al.: "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19332-9, 2001 (PubMed).