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Cadherin 12 (AA 62-90), (N-Term) antibody

Details for Product No. ABIN388271, Supplier: Log in to see
Antigen
  • Cdhb
  • RGD1566350
  • CDHB
Epitope
AA 62-90, N-Term
16
14
9
7
4
2
2
2
1
1
1
1
1
Reactivity
Human
74
15
15
1
1
Host
Rabbit
66
8
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
10
9
9
4
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
51
44
36
11
7
2
1
Supplier
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Immunogen This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 AA from the N-terminal region of human CDH12.
Clone RB13742
Isotype Ig
Specificity This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69~98 amino acids from the N-terminal region of human CDH12.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDH12
Background CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonyms: Brain cadherin, BR-cadherin, N-cadherin 2, Neural type cadherin 2
Molecular Weight 88351 DA
Gene ID 1010
UniProt P55289
Research Area Stem Cells, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cadherin 12 (AA 62-90), (N-Term) antibody (ABIN388271) Western blot analysis of anti-CDH12 Antibody (N-term) (ABIN388271) in Jurkat cell lin...
Immunohistochemistry (IHC) image for anti-Cadherin 12 (AA 62-90), (N-Term) antibody (ABIN388271) Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 antibody (...
Background publications Shimoyama, Tsujimoto, Kitajima et al.: "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." in: The Biochemical journal, Vol. 349, Issue Pt 1, pp. 159-67, 2001 (PubMed).

Kremmidiotis, Baker, Crawford et al.: "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity." in: Genomics, Vol. 49, Issue 3, pp. 467-71, 1998 (PubMed).

Selig, Lidov, Bruno et al.: "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2398-403, 1997 (PubMed).