Cadherin 12 (N-Term), (AA 62-90) antibody

Details for Product No. ABIN388271
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Synonyms CDHB, Cdhb, RGD1566350
N-Term, AA 62-90
(4), (3), (2), (1), (1), (1), (1), (1)
(30), (13), (13), (1), (1)
(28), (3)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB), Immunohistochemistry (IHC)
(22), (13), (10), (8), (7), (1)
Pubmed 3 references available
Catalog no. ABIN388271
Quantity 400 µL
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Immunogen This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 AA from the N-terminal region of human CDH12.
Clone RB13742
Isotype Ig
Specificity This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69~98 amino acids from the N-terminal region of human CDH12.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDH12
Background CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonyms: Brain cadherin, BR-cadherin, N-cadherin 2, Neural type cadherin 2
Molecular Weight 88351 DA
Gene ID 1010
UniProt P55289
Research Area Stem Cells, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cadherin 12 (N-Term), (AA 62-90) antibody Western blot analysis of anti-CDH12 Antibody (N-term) (ABIN388271) in Jurkat cell line lysates (35 µg/lane). CDH12(arrow) was detected using the purified polyclonal antibody (1:60 dilution).
anti-Cadherin 12 (N-Term), (AA 62-90) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 antibody (N-term) (ABIN388271), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Selig, Lidov, Bruno et al.: "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2398-403, 1997 (PubMed).

Kremmidiotis, Baker, Crawford et al.: "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity." in: Genomics, Vol. 49, Issue 3, pp. 467-71, 1998 (PubMed).

Shimoyama, Tsujimoto, Kitajima et al.: "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." in: The Biochemical journal, Vol. 349, Issue Pt 1, pp. 159-67, 2001 (PubMed).

Hosts (28), (3)
Reactivities (30), (13), (13), (1), (1)
Applications (22), (13), (10), (8), (7), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (1), (1), (1), (1), (1)
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