Cadherin 12 (N-Term), (AA 62-90) antibody

Details for Product No. ABIN388271
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Antigen
Epitope
N-Term, AA 62-90
(10), (9), (6), (6), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(46), (13), (13), (1), (1)
Host
Rabbit
(44), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(38), (26), (23), (10), (8), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN388271
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Immunogen This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 AA from the N-terminal region of human CDH12.
Clone RB13742
Isotype Ig
Specificity This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69~98 amino acids from the N-terminal region of human CDH12.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDH12
Background CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonyms: Brain cadherin, BR-cadherin, N-cadherin 2, Neural type cadherin 2
Molecular Weight 88351 DA
Gene ID 1010
UniProt P55289
Research Area Stem Cells, Cell Structure, Neurology
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cadherin 12 (N-Term), (AA 62-90) antibody Western blot analysis of anti-CDH12 Antibody (N-term) (ABIN388271) in Jurkat cell line lysates (35 µg/lane). CDH12(arrow) was detected using the purified polyclonal antibody (1:60 dilution).
anti-Cadherin 12 (N-Term), (AA 62-90) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with CDH12 antibody (N-term) (ABIN388271), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Selig, Lidov, Bruno et al.: "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2398-403, 1997 (PubMed).

Kremmidiotis, Baker, Crawford et al.: "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity." in: Genomics, Vol. 49, Issue 3, pp. 467-71, 1998 (PubMed).

Shimoyama, Tsujimoto, Kitajima et al.: "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." in: The Biochemical journal, Vol. 349, Issue Pt 1, pp. 159-67, 2001 (PubMed).

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