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Details for Product No. ABIN388272

Cadherin 12 (C-Term), (AA 688-716) antibody

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Antigen
Synonyms CDHB, Cdhb, RGD1566350
Epitope
»Alternatives C-Term, AA 688-716
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN388272
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-716 AA from the C-terminal region of human CDH12.
Clone RB12870
Isotype Ig
Specificity This CDH12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 695~724 amino acids from the C-terminal region of human CDH12.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CDH12
Background CDH12 is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonyms: Brain cadherin, BR-cadherin, N-cadherin 2, Neural type cadherin 2
Molecular Weight 88351 DA
Gene ID 1010
UniProt P55289
Research Area Stem Cells, Cell Structure, Neurology
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Selig, Lidov, Bruno et al.: "Molecular characterization of Br-cadherin, a developmentally regulated, brain-specific cadherin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2398-403, 1997 (PubMed).

Kremmidiotis, Baker, Crawford et al.: "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity." in: Genomics, Vol. 49, Issue 3, pp. 467-71, 1998 (PubMed).

Shimoyama, Tsujimoto, Kitajima et al.: "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins." in: The Biochemical journal, Vol. 349, Issue Pt 1, pp. 159-67, 2001 (PubMed).

Alternatives for antigen "Cadherin 12", type "Antibodies"
Hosts (28), (3)
Reactivities (30), (13), (13), (1), (1)
Applications (22), (14), (10), (8), (7), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (2), (2), (1), (1), (1), (1)
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