|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (C-Term) antibody
|Synonyms||Nac1, Btbd14b, 2010001H03Rik, 4930511N13Rik, NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, Nac-1|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||Nac1 (BTBD14B)|
|Immunogen||This BTBD14B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414~444 amino acids from the C-terminal region of human BTBD14B.|
|Description||Other names: BTB/POZ domain-containing protein 14B, Nucleus accumbens-1, NAC1|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This BTBD14B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414~444 amino acids from the C-terminal region of human BTBD14B.|
|Molecular Weight||57258 DA|
Background: BTBD14B functions as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. In humans the protein is upregulated in a number of carcinomas and is localized in discrete nuclear bodies that correlate with tumour recurrence.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50:100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Cancer, Transcription Factors, Signaling, Neurology, Cell Structure|
|Restrictions||For Research Use only|
|Western blot analysis of BTBD14B Antibody (C-term) in mouse heart tissue lysates (35ug/lane). BTBD14B (arrow) was detected using the purified Pab (1:60 dilution).|
Nakayama, Nakayama, Davidson et al.: "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 49, pp. 18739-44, 2006 (PubMed).
Davidson, Berner, Trope et al.: "Expression and clinical role of the bric-a-brac tramtrack broad complex/poxvirus and zinc protein NAC-1 in ovarian carcinoma effusions." in: Human pathology, Vol. 38, Issue 7, pp. 1030-6, 2007 (PubMed).
Nakayama, Nakayama, Wang et al.: "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor." in: Cancer research, Vol. 67, Issue 17, pp. 8058-64, 2007 (PubMed).
|Hosts||Rabbit (12), Mouse (5), Goat (4)|
|Reactivities||Human (20), Mouse (Murine) (6), Dog (Canine) (4), Rat (Rattus) (4), Cow (Bovine) (3)|
|Applications||Western Blotting (WB) (19), ELISA (9), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Immunocytochemistry (ICC) (1), Immunofluorescence (IF) (1)|
|Epitopes||C-Term (5), Internal Region (3)|