Toll-Like Receptor 2 (TLR2) (N-Term), (AA 212-242) antibody

Details for Product No. ABIN388327
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Antigen
Synonyms TIL4, CD282, Ly105
Epitope
N-Term, AA 212-242
(20), (14), (6), (5), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(275), (120), (17), (17), (13), (13), (12), (3), (1), (1), (1)
Host
Rabbit
(226), (74), (34), (5), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(41), (39), (26), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(193), (125), (93), (71), (42), (40), (30), (29), (24), (24), (20), (10), (3), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN388327
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-242 AA from the N-terminal region of human TLR2.
Clone RB02403-02404
Isotype Ig
Specificity This TLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 219~249 amino acids from the N-terminal region of human TLR2.
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name TLR2
Background The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
Molecular Weight 89837 DA
Gene ID 7097
UniProt O60603
Research Area Apoptosis/Necrosis, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Toll-Like Receptor 2 (TLR2) (N-Term), (AA 212-242) antibody Western blot analysis of hTLR2-C226 (ABIN388327) in K562 cell line lysates (35 µg/lane). TLR2 (arrow) was detected using the purified polyclonal antibody.
anti-Toll-Like Receptor 2 (TLR2) (N-Term), (AA 212-242) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Toll-Like Receptor 2 (TLR2) (N-Term), (AA 212-242) antibody (3) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TLR2 antibody (N-term) (ABIN388327), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Takeuchi, Watari, Shinya et al.: "Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells." in: Biochemical and biophysical research communications, Vol. 306, Issue 3, pp. 674-9, 2003 (PubMed).

Meng, Grabiec, Vallon et al.: "Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2." in: The Journal of biological chemistry, Vol. 278, Issue 41, pp. 39822-9, 2003 (PubMed).

Huang, Aliberti, Leifer et al.: "Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 3, pp. 1441-6, 2003 (PubMed).

Wang, Zhang, Louboutin et al.: "Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 12, pp. 1727-9, 2003 (PubMed).

Sandor, Latz, Re et al.: "Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling." in: The Journal of cell biology, Vol. 162, Issue 6, pp. 1099-110, 2003 (PubMed).

Hosts (226), (74), (34), (5), (4)
Reactivities (275), (120), (17), (17), (13), (13), (12), (3), (1), (1), (1)
Applications (193), (125), (93), (71), (42), (40), (30), (29), (24), (24), (20), (10), (3), (1), (1), (1), (1)
Conjugates (41), (39), (26), (6), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (14), (6), (5), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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