Gap Junction Protein, alpha 1, 43kDa (GJA1) (N-Term), (AA 107-138) antibody

Details for Product No. ABIN388369
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Antigen
Synonyms
cx43, gjal, oddd, dfnb38, connexin43, cx43a1, gja1, zfCx43.3, AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, AVSD3, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD, connexin 43, gja1-A, Cnx46, Cx46, G ... show more
cx43, gjal, oddd, dfnb38, connexin43, cx43a1, gja1, zfCx43.3, AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, AVSD3, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD, connexin 43, gja1-A, Cnx46, Cx46, Gja-3, AI118175, Cnx32, Cx32, Gjb-1 show less
Epitope
N-Term, AA 107-138
(36), (28), (23), (15), (9), (8), (7), (5), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(207), (135), (119), (44), (44), (24), (19), (8), (8), (7), (7), (5), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(213), (13), (10)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(176), (79), (76), (63), (33), (30), (16), (14), (7), (5), (2), (1), (1)
Pubmed 6 references available
Quantity 400 μL
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Catalog No. ABIN388369
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Immunogen This Connexin 43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-138 AA from the N-terminal region of human Connexin 43.
Clone RB01369
Isotype Ig
Specificity This Connexin 43 Antibody antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114~144 amino acids from the N-terminal region of human GJA1.
Predicted Reactivity Cow (Bovine),Xenopus laevis
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Connexin 43 (GJA1)
Background Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.
Synonyms: Gap junction alpha-1 protein, Connexin 43, Cx43, Gap junction 43 kDa heart protein
Molecular Weight 42877 DA
Gene ID 2697
UniProt P17302
Research Area Stem Cells, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.7 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (N-Term), (AA 107-138) antibody (LEFT)Western blot analysis of anti-GJA1 Antibody (N-term)(ABIN388369) in CEM cell line lysates (35 µg/lane). GJA1(arrow) was detected using the purified polyclonal antibody. (RIGHT)Western blot analysis of hGJA1-N121.Connexin (ABIN388369) in mouse brain tissue lysates (35 µg/lane).GJA1 (arrow) was detected using the purified polyclonal antibody.
anti-Gap Junction Protein, alpha 1, 43kDa (GJA1) (N-Term), (AA 107-138) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Cameron, Malik, Akaike et al.: "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18682-8, 2003 (PubMed).

Ma, Ma, Sui et al.: "Signal transduction of gap junctional genes, connexin32, connexin43 in human hepatocarcinogenesis." in: World journal of gastroenterology : WJG, Vol. 9, Issue 5, pp. 946-50, 2003 (PubMed).

Qin, Shao, Igdoura et al.: "Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30005-14, 2003 (PubMed).

Spinella, Rosanò, Di Castro et al.: "Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells." in: The Journal of biological chemistry, Vol. 278, Issue 42, pp. 41294-301, 2003 (PubMed).

Contreras, Sáez, Bukauskas et al.: "Gating and regulation of connexin 43 (Cx43) hemichannels." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 20, pp. 11388-93, 2003 (PubMed).

General Li, Zhang, Jiao et al.: "Knockdown of microRNA-181 by lentivirus mediated siRNA expression vector decreases the arrhythmogenic effect of skeletal myoblast transplantation in rat with myocardial infarction." in: Microvascular research, Vol. 78, Issue 3, pp. 393-404, 2009 (PubMed).

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