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ATG4C antibody (N-Term)

ATG4C Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB7561 unconjugated
Catalog No. ABIN388503
  • Target See all ATG4C Antibodies
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    Binding Specificity
    • 15
    • 15
    • 11
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 33-62, N-Term
    Reactivity
    • 66
    • 29
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 59
    • 11
    • 2
    • 1
    Rabbit
    Clonality
    • 63
    • 10
    Polyclonal
    Conjugate
    • 30
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATG4C antibody is un-conjugated
    Application
    • 67
    • 29
    • 24
    • 23
    • 13
    • 13
    • 13
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ATG4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human ATG4C.
    Clone
    RB7561
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ATG4C Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))
    Alternative Name
    ATG4C (ATG4C Products)
    Synonyms
    apg4c antibody, atg4cl antibody, zgc:86888 antibody, wu:fc56g07 antibody, APG4-C antibody, APG4C antibody, AUTL1 antibody, AUTL3 antibody, Apg4-C antibody, Apg4c antibody, Atg4cl antibody, Autl1 antibody, autophagy related 4C cysteine peptidase antibody, autophagy related 4C, cysteine peptidase antibody, cysteine protease ATG4C antibody, ATG4C antibody, atg4c antibody, Tsp_15996 antibody, Atg4c antibody
    Background
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
    Molecular Weight
    52497
    Gene ID
    84938
    NCBI Accession
    NP_116241, NP_835739
    UniProt
    Q96DT6
    Pathways
    Autophagy
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