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GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN388564, Supplier: Log in to see
Antigen
  • GABARAP
  • ATG8A
  • GABARAP-a
  • MM46
  • gabarap
  • mg:bb02b03
Epitope
AA 1-30, N-Term
48
21
13
3
3
2
2
1
1
1
1
Reactivity
Human
110
70
28
1
1
1
1
Host
Rabbit
125
18
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
10
10
10
5
5
5
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
125
50
27
20
11
5
4
1
1
Supplier
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Immunogen This GABARAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human GABARAP.
Clone RB11846
Isotype Ig
Specificity This GABARAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~31 amino acids from the N-terminal region of human GABARAP.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name GABARAP (GABARAP Antibody Abstract)
Background Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. GABARAP is GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.
Synonyms: Gamma-aminobutyric acid receptor-associated protein, GABA(A) receptor-associated protein, MM46, GABARAP, FLC3B,
Molecular Weight 13918 DA
Gene ID 11337
UniProt O95166
Research Area Autophagy, Cell Structure
Application Notes IF = 1:10-50, WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30), (N-Term) antibody (ABIN388564) Western blot analysis of GABARAP (arrow) using purified polyclonal antibody (ABIN3885...
Western Blotting (WB) image for anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30), (N-Term) antibody (ABIN388564) Western blot done using standard conditions on WT MEFs, starved with EBSS for 2 hours...
 image for anti-GABA(A) Receptor-Associated Protein (GABARAP) (AA 1-30), (N-Term) antibody (ABIN388564) Rabbit anti-GABARAP Abgent ABIN388564 1:75 dilution in 5% scimmed milk powder. Second...
Product cited in: Egan, Chun, Vamos et al.: "Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates." in: Molecular cell, Vol. 59, Issue 2, pp. 285-97, 2015 (PubMed).

Background publications Tanida, Tanida-Miyake, Komatsu et al.: "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13739-44, 2002 (PubMed).

Knight, Harris, McAlister et al.: "The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5556-61, 2002 (PubMed).