|+1 404 474 4654|
|+1 888 205 9894 (TF)|
DNA-Damage Regulated Autophagy Modulator 2 (DRAM2) (C-Term) antibody
|Synonyms||DRAM, FLJ11259, Dram, 1200002N14Rik, PRO180, TMEM77, WWFQ154, MGC54289, RP5-1180E21.1, fj35e01, zgc:86754, wu:fj35e01, dram, DRAM1, flj11259, MGC108229, MGC187403, DRAM2, MGC128340|
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|2 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Alternative name||DRAM -2|
|Immunogen||This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DRAM.|
|Description||Other names: Damage-regulated autophagy modulator|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DRAM.|
|Molecular Weight||26122 DA|
Background: DRAM is regulated as part of the p53 tumor suppressor pathway. It is a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of the gene encoding DRAM is associated with various tumors.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100 Immunohistochemistry ~~ 1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure, Cancer, Autophagy, Transcription Factors, Signaling|
|Restrictions||For Research Use only|
Green, Chipuk: "p53 and metabolism: Inside the TIGAR." in: Cell, Vol. 126, Issue 1, pp. 30-2, 2006 (PubMed).
Kerley-Hamilton, Pike, Hutchinson et al.: "The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins." in: Biochimica et biophysica acta, Vol. 1769, Issue 4, pp. 209-19, 2007 (PubMed).