UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 666-699)

Details for Product anti-UVRAG Antibody No. ABIN388586, Supplier: Log in to see
Antigen
  • CG6116
  • Dmel\\CG6116
  • UVRAG
  • Uvrag1
  • zgc:56164
  • uvrag
  • MGC81810
  • MGC131135
  • DHTX
  • VPS38
  • p63
  • 9530039D02Rik
  • AI648770
  • BB124205
  • Uvragl
  • UV-resistance associated gene
  • UV radiation resistance associated gene
  • UV radiation resistance associated
  • Uvrag
  • uvrag
  • UVRAG
  • Uvrag1
Epitope
AA 666-699, C-Term
27
3
3
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3
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2
1
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Reactivity
Human, Mouse (Murine)
103
74
63
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3
2
2
2
2
2
2
1
1
Host
Rabbit
87
16
Clonality (Clone)
Polyclonal ()
Conjugate
This UVRAG antibody is un-conjugated
3
3
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1
1
1
1
1
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1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
75
52
37
15
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13
8
7
4
2
2
1
Options
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Immunogen This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 AA from the C-terminal region of human UVRAG.
Clone RB10849
Isotype Ig
Specificity This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 670~699 amino acids from the C-term of human UVRAG.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UVRAG (UVRAG Antibody Abstract)
Background UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Synonyms: UV radiation resistance-associated gene protein, p63
Molecular Weight 78151 Da
Gene ID 7405
UniProt Q9P2Y5
Research Area Cell Signaling, Cancer, Autophagy, Cell Structure
Application Notes IF = 1:10-50, WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 666-699) (ABIN388586) Immunoprecipitation and western blot analysis of anti-UVRAG Pab (ABIN388586) in 293T ...
Immunohistochemistry (IHC) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 666-699) (ABIN388586) Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388586) on Methanol-fixe...
Immunohistochemistry (IHC) image for anti-UVRAG antibody (UV Radiation Resistance Associated Gene) (AA 666-699) (ABIN388586) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG...
Product cited in: Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Sun, Zhang, Fan, Wong, Ding, Chen, Zhong: "The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression." in: The Journal of biological chemistry, Vol. 286, Issue 1, pp. 185-91, 2011 (PubMed).

Neely, Green, LaFerla: "Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a ?-secretase-independent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 8, pp. 2781-91, 2011 (PubMed).

Sun, Westphal, Wong, Tan, Zhong: "Rubicon controls endosome maturation as a Rab7 effector." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 45, pp. 19338-43, 2010 (PubMed).

Gao, Kang, Liao, Ding, Gambotto, Watkins, Liu, Stolz, Yin: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, 2010 (PubMed).

Sun, Fan, Chen, Ding, Chen, Zhong: "Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 49, pp. 19211-6, 2008 (PubMed).

Han, Hou, Goldstein, Lu, Stolz, Yin, Rabinowich: "Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19665-77, 2008 (PubMed).

Background publications Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, 2006 (PubMed).

Ionov, Nowak, Perucho, Markowitz, Cowell: "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability." in: Oncogene, Vol. 23, Issue 3, pp. 639-45, 2004 (PubMed).

Perelman, Dafni, Naiman, Eli, Yaakov, Feng, Sinha, Weber, Khodaei, Sancar, Dotan, Canaani: "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." in: Genomics, Vol. 41, Issue 3, pp. 397-405, 1997 (PubMed).

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