UV Radiation Resistance Associated Gene (UVRAG) (C-Term), (AA 666-699) antibody

Details for Product No. ABIN388586
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Antigen
Synonyms DHTX, VPS38, p63, Uvrag1, Uvragl, AI648770, BB124205, 9530039D02Rik, CG6116, Dmel\\CG6116, UVRAG, zgc:56164, uvrag, MGC81810, MGC131135
Epitope
C-Term, AA 666-699
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(28), (18), (15), (12), (1)
Host
Rabbit
(23), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)
(18), (10), (9), (8), (7), (2), (2), (2), (1), (1)
Pubmed 3 references available
Catalog no. ABIN388586
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-699 AA from the C-terminal region of human UVRAG.
Clone RB10849
Isotype Ig
Specificity This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 670~699 amino acids from the C-term of human UVRAG.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UVRAG
Background UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Synonyms: UV radiation resistance-associated gene protein, p63
Molecular Weight 78151 Da
Gene ID 7405
UniProt Q9P2Y5
Research Area Cell Signaling, Cancer, Autophagy, Cell Structure
Application Notes IF = 1:10-50, WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-UV Radiation Resistance Associated Gene (UVRAG) (C-Term), (AA 666-699) antibody Immunoprecipitation and western blot analysis of anti-UVRAG Pab (ABIN388586) in 293T cells. UVRAG is immunoprecipitated (Lane 2) and detected in 293T cell transiently transfected with mouse UVRAG (Lane 1). Detection of endogenous UVRAG is shown in 293T cells (Lane 3) but is reduced by UVRAG siRNA transfection (Lane 4). Data courtesy of Dr. Hong-Gang Wang, Moffitt Cancer Center, Tampa, FL.
anti-UV Radiation Resistance Associated Gene (UVRAG) (C-Term), (AA 666-699) antibody (2) Immunofluorescence staining of Autophagy UVRAG antibody (ABIN388586) on Methanol-fixed HeLa cells. Data courtesy of Dr. Eeva-Liisa Eskelinen, University of Helsinki,Finland.
anti-UV Radiation Resistance Associated Gene (UVRAG) (C-Term), (AA 666-699) antibody (3) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Perelman, Dafni, Naiman et al.: "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." in: Genomics, Vol. 41, Issue 3, pp. 397-405, 1997 (PubMed).

Ionov, Nowak, Perucho et al.: "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability." in: Oncogene, Vol. 23, Issue 3, pp. 639-45, 2004 (PubMed).

Liang, Feng, Ku et al.: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, 2006 (PubMed).

Hosts (23), (5)
Reactivities (28), (18), (15), (12), (1)
Applications (18), (10), (9), (8), (7), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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