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PIK3C3 antibody (C-Term)

PIK3C3 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB10857 unconjugated
Catalog No. ABIN388591
  • Target See all PIK3C3 Antibodies
    PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
    Binding Specificity
    • 26
    • 22
    • 22
    • 16
    • 13
    • 12
    • 12
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 770-801, C-Term
    Reactivity
    • 200
    • 61
    • 55
    • 3
    • 1
    Human
    Host
    • 198
    • 2
    Rabbit
    Clonality
    • 191
    • 9
    Polyclonal
    Conjugate
    • 54
    • 22
    • 21
    • 20
    • 17
    • 16
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIK3C3 antibody is un-conjugated
    Application
    • 159
    • 113
    • 95
    • 40
    • 39
    • 30
    • 23
    • 18
    • 16
    • 16
    • 15
    • 9
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    M, Pig, Rat
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PI3KC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 770-801 amino acids from the C-terminal region of human PI3KC3.
    Clone
    RB10857
    Top Product
    Discover our top product PIK3C3 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Delaney, Patel, Willis, Haghighiabyaneh, Axelrod, Tancioni, Lu, Bapat, Young, Cadassou, Bartakova, Sheth, Haft, Hui, Saenz, Schlaepfer, Harismendy, Stupack: "Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer." in: Nature communications, Vol. 8, pp. 14423, (2017) (PubMed).

    Liu, Ji, Zhou, Xing: "Phosphatidylinositol 3-Kinase Promotes Activation and Vacuolar Acidification and Delays Methyl Jasmonate-Induced Leaf Senescence." in: Plant physiology, Vol. 170, Issue 3, pp. 1714-31, (2016) (PubMed).

  • Target
    PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))
    Alternative Name
    PI3KC3 (PIK3C3 Products)
    Synonyms
    im:7147158 antibody, wu:fc13g06 antibody, wu:fz51e12 antibody, zgc:112016 antibody, zgc:113009 antibody, VPS34 antibody, hVps34 antibody, 5330434F23Rik antibody, Vps34 antibody, phosphatidylinositol 3-kinase catalytic subunit type 3 antibody, phosphatidylinositol 3-kinase catalytic subunit type 3 L homeolog antibody, phosphatidylinositol 3-kinase, catalytic subunit type 3 antibody, PIK3C3 antibody, pik3c3.L antibody, pik3c3 antibody, Pik3c3 antibody
    Background
    PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
    Molecular Weight
    101549
    Gene ID
    5289
    NCBI Accession
    NP_002638
    UniProt
    Q8NEB9
    Pathways
    AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy
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