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UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) (AA 297-326), (N-Term) antibody

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Synonyms RENT1, Tb05.3C6.50, AO090012000584, rent1, wu:fi40f07, wu:fj48a01, zgc:55472, HUPF1, NORF1, pNORF1, smg-2, B430202H16Rik, PNORF-1, Rent1, Upflp
AA 297-326, N-Term
(10), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(60), (26), (21), (2), (1), (1), (1), (1), (1)
(50), (8), (4)
Clonality (Clone)
Polyclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(47), (14), (12), (11), (8), (6), (3), (3), (2), (1), (1)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 AA from the N-terminal region of human RENT1.
Clone RB8352
Isotype Ig
Specificity This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304~334 amino acids from the N-terminal region of human RENT1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RENT1 (UPF1 Antibody Abstract)
Background RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
Synonyms: Regulator of nonsense transcripts 1, ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1,
Molecular Weight 124345 DA
Gene ID 5976
UniProt Q92900
Research Area Translation Factors, Cell Signaling, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) (AA 297-326), (N-Term) antibody (ABIN388607) Western blot analysis of RENT1 (arrow) using rabbit polyclonal RENT1 Antibody (N-term...
Product cited in: Kang, Shen, Macdonald: "Two molecular pathways (NMD and ERAD) contribute to a genetic epilepsy associated with the GABA(A) receptor GABRA1 PTC mutation, 975delC, S326fs328X." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 9, pp. 2833-44, 2009 (PubMed).

Background publications Ohnishi, Yamashita, Kashima et al.: "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." in: Molecular cell, Vol. 12, Issue 5, pp. 1187-200, 2003 (PubMed).

Mendell, ap Rhys, Dietz: "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts." in: Science (New York, N.Y.), Vol. 298, Issue 5592, pp. 419-22, 2002 (PubMed).

Catalog No. ABIN388607
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