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Details for Product No. ABIN388607

UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1) (N-Term), (AA 297-326) antibody

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Antigen
Synonyms HUPF1, NORF1, RENT1, pNORF1, smg-2, Rent1, Upflp, PNORF-1, B430202H16Rik, rent1, zgc:55472, wu:fi40f07, wu:fj48a01, Tb05.3C6.50, AO090012000584
Epitope
»Alternatives N-Term, AA 297-326
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN388607
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 AA from the N-terminal region of human RENT1.
Clone RB8352
Isotype Ig
Specificity This RENT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304~334 amino acids from the N-terminal region of human RENT1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RENT1
Background RENT1 is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping.
Synonyms: Regulator of nonsense transcripts 1, ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog, hUpf1, RENT1, KIAA0221, UPF1,
Molecular Weight 124345 DA
Gene ID 5976
UniProt Q92900
Research Area Translation Factors, Cell Signaling, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Mendell, ap Rhys, Dietz: "Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts." in: Science (New York, N.Y.), Vol. 298, Issue 5592, pp. 419-22, 2002 (PubMed).

Ohnishi, Yamashita, Kashima et al.: "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7." in: Molecular cell, Vol. 12, Issue 5, pp. 1187-200, 2003 (PubMed).

Alternatives for antigen "UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF1)", type "Antibodies"
Hosts (31), (9), (2)
Reactivities (41), (24), (15), (13), (13), (13), (4), (1)
Applications (29), (14), (10), (6), (4), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (2), (2), (1), (1), (1)
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