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Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa (EIF2B3) (C-Term), (AA 344-376) antibody

Details for Product No. ABIN388637
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Antigen
Epitope
C-Term, AA 344-376
(8), (7), (4), (2), (2), (2)
Reactivity
Human
(31), (6), (4), (1)
Host
Rabbit
(21), (11)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (14), (7), (6), (2), (2)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN388637
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Immunogen This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 344-376 AA from the C-terminal region of human EIF2B3.
Clone RB8435
Isotype Ig
Specificity This EIF2B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EIF2B3.
Predicted Reactivity Monkey
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EIF2B3
Background EIF2B3 catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutations in each of the five subunits of translation initiation factor eIF2B, including subunit 3, can cause leukoencephalopathy with vanishing white matter. EIF2B3 has also been identified as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation.
Synonyms: Translation initiation factor eIF-2B gamma subunit, eIF-2B GDP-GTP exchange factor, EIF2B3,
Molecular Weight 50,24 DA
Gene ID 8891
UniProt Q9NR50
Research Area Translation Factors, Cell Signaling, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Eukaryotic Translation Initiation Factor 2B, Subunit 3 Gamma, 58kDa (EIF2B3) (C-Term), (AA 344-376) antibody Western blot analysis of EIF2B3 (arrow) using rabbit polyclonal EIF2B3 Antibody (ABIN388637). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EIF2B3 gene.
Background publications Gomez, Pavitt: "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation." in: Molecular and cellular biology, Vol. 20, Issue 11, pp. 3965-76, 2000 (PubMed).

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