Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (C-Term), (AA 472-502) antibody

Details for Product No. ABIN388739
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Antigen
Epitope
C-Term, AA 472-502
(19), (12), (8), (8), (7), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(84), (28), (18), (17), (17), (1), (1)
Host
Rabbit
(78), (9)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(7), (6), (6), (6), (6), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(68), (44), (21), (17), (14), (9), (3), (2), (2)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN388739
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Immunogen This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-502 AA from the C-terminal region of human BMPR1B.
Clone RB01776
Isotype Ig
Specificity This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473~502 amino acids from the C-terminal region of human BMPR1B.
Predicted Reactivity Chicken,Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name BMPR1B
Background The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
Synonyms: Serine(threonine) protein kinase, activin receptor-like kinase 6, ALK6
Molecular Weight 56930 DA
Gene ID 658
NCBI Accession NP_001194
Research Area Phospho-specific antibodies, Stem Cells, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (C-Term), (AA 472-502) antibody Western blot analysis of anti-BMPR1B Pab (ABIN388739) in NCI-H460 cell lysate. BMPR1B (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Bone Morphogenetic Protein Receptor, Type IB (BMPR1B) (C-Term), (AA 472-502) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications ten Dijke, Yamashita, Ichijo et al.: "Characterization of type I receptors for transforming growth factor-beta and activin." in: Science (New York, N.Y.), Vol. 264, Issue 5155, pp. 101-4, 1994 (PubMed).

Lehmann, Seemann, Stricker et al.: "Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 21, pp. 12277-82, 2003 (PubMed).

General Kan, Liu, McGuire et al.: "Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification." in: Stem cells (Dayton, Ohio), Vol. 27, Issue 1, pp. 150-6, 2009 (PubMed).

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