Add to Basket Bulk discount
Order hotline:
+1 404 474 4654
+1 888 205 9894 (TF)

SRY (Sex Determining Region Y)-Box 2 (SOX2) (Center) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Binding Site
Alternatives

Center
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN388796
Quantity 400 µL  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
Bulk discount
Shipping to
Availability Will be delivered in 2 to 3 Business Days

anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (Center) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name SOX2
Gene ID 6657
UniProt P48431
Immunogen This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino acids from the Center region of human SOX2.
Isotype Ig
Description Other names: Transcription factor SOX-2
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino acids from the Center region of human SOX2.
Molecular Weight 34310 DA
Comments

Background: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.

Application Details
Publications Images Alternatives back to top

Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Stem Cells, Transcription Factors, Signaling
Restrictions For Research Use only

Publications
Application Details Images Alternatives back to top

Product Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Reményi, Lins, Nissen et al.: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (89), Mouse (19), Goat (4)
Reactivities Human (107), Mouse (Murine) (41), Rat (Rattus) (32), Dog (Canine) (23), Pig (Porcine) (23), Chicken (22), Cow (Bovine) (22), Sheep (Ovine) (20), Guinea Pig (18), Xenopus laevis (2), Zebrafish (2), Zebrafish (Danio rerio) (2), Cat (Feline) (1), Chimpanzee (1), Monkey (1), Opossum (Didelphimorphia) (1), Rhesus Monkey (1), Salmon (Salmonidae) (1)
Applications Western Blotting (WB) (77), ELISA (56), Immunofluorescence (IF) (33), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (14), Immunocytochemistry (ICC) (10), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (9), C-Term (3), AA 1-170 (2), Ala30 (2), Cys265 (2), Internal Region (2), AA 50-100 (1), C-Term, AA 240-260 (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)