SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term), (AA 89-119) antibody

Details for Product No. ABIN388797
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Antigen
Synonyms ANOP3, MCOPS3, RGD1565646, Qsox, rSOx, Qscn6, Sox-2, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389, SRY-box2, Xsox-2, anop3, mcops3, sox-2
Epitope
N-Term, AA 89-119
(25), (6), (6), (5), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(148), (63), (43), (21), (20), (20), (16), (12), (5), (4), (4), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(123), (33), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(117), (45), (33), (28), (26), (19), (12), (11), (10), (4), (2), (1), (1)
Pubmed 5 references available
Catalog no. ABIN388797
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-119 AA from the N-terminal region of human SOX2.
Clone RB14026
Isotype Ig
Specificity This SOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97~126 amino acids from the N-terminal region of human SOX2.
Predicted Reactivity Chicken,Mouse (Murine),Xenopus laevis,Zebrafish
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SOX2
Background The intronless gene for SOX2 encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
Synonyms: Transcription factor SOX-2
Molecular Weight 34310 Da. MW based on amino acid sequence. Theoretical pI: 9.74 Da
Gene ID 6657
UniProt P48431
Research Area Stem Cells, Transcription Factors, Signaling
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term), (AA 89-119) antibody Western blot analysis of SOX2 Antibody (N-term) in 293 cell line lysates (35 µg/lane). SOX2(arrow) was detected using the purified polyclonal antibody.
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term), (AA 89-119) antibody (2) Western blot analysis of SOX2 (arrow) using rabbit polyclonal SOX2 Antibody (N-term) (ABIN388797). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the SOX2 gene (Lane 2) (Origene Technologies).
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (N-Term), (AA 89-119) antibody (3) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SOX2 antibody (N-term) (ABIN388797), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Reményi, Lins, Nissen et al.: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Hosts (123), (33), (5)
Reactivities (148), (63), (43), (21), (20), (20), (16), (12), (5), (4), (4), (3), (2), (2), (1), (1), (1)
Applications (117), (45), (33), (28), (26), (19), (12), (11), (10), (4), (2), (1), (1)
Conjugates (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (25), (6), (6), (5), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
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