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SLUG (AA 1-30), (N-Term) antibody

Details for Product No. ABIN388808, Supplier: Log in to see
Antigen
Epitope
AA 1-30, N-Term
13
6
4
3
2
1
1
1
1
1
Reactivity
Human
39
28
20
2
2
2
Host
Rabbit
37
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
26
11
11
5
4
4
1
Supplier
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Immunogen This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human SLUG.
Clone RB15389
Isotype Ig
Specificity This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2~32 amino acids from the N-terminal region of human SLUG.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. This protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in the gene encoding SLUG may be associated with sporadic cases of neural tube defects.
Synonyms: Zinc finger protein SLUG, Neural crest transcription factor Slug, Snail homolog 2,SNAI2
UniProt O43623
Research Area Apoptosis/Necrosis, Stem Cells, Transcription Factors, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SLUG (AA 1-30), (N-Term) antibody (ABIN388808) (LEFT)Western blot analysis of anti-SLUG Antibody (N-term K9) Pab (ABIN388808) in A20...
Product cited in: Huo, Kao, Chuu: "Androgen receptor inhibits epithelial-mesenchymal transition, migration, and invasion of PC-3 prostate cancer cells." in: Cancer letters, Vol. 369, Issue 1, pp. 103-11, 2015 (PubMed).

Liang, Wang, Li et al.: "miR-33a suppresses the nuclear translocation of ?-catenin to enhance gemcitabine sensitivity in human pancreatic cancer cells." in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015 (PubMed).

Huang, Chen, Chang et al.: "Hepatocyte growth factor activates Wnt pathway by transcriptional activation of LEF1 to facilitate tumor invasion." in: Carcinogenesis, Vol. 33, Issue 6, pp. 1142-8, 2012 (PubMed).

Collado, Thiede, Baker et al.: "The postnatal accumulation of junctional E-cadherin is inversely correlated with the capacity for supporting cells to convert directly into sensory hair cells in mammalian balance organs." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 33, pp. 11855-66, 2011 (PubMed).

Fu, Lv, Lin et al.: "Ubiquitin ligase cullin 7 induces epithelial-mesenchymal transition in human choriocarcinoma cells." in: The Journal of biological chemistry, Vol. 285, Issue 14, pp. 10870-9, 2010 (PubMed).

Background publications Sánchez-Martín, Rodríguez-García, Pérez-Losada et al.: "SLUG (SNAI2) deletions in patients with Waardenburg disease." in: Human molecular genetics, Vol. 11, Issue 25, pp. 3231-6, 2002 (PubMed).

Hajra, Chen, Fearon: "The SLUG zinc-finger protein represses E-cadherin in breast cancer." in: Cancer research, Vol. 62, Issue 6, pp. 1613-8, 2002 (PubMed).

Hemavathy, Guru, Harris et al.: "Human Slug is a repressor that localizes to sites of active transcription." in: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, 2000 (PubMed).