Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term), (AA 16-46) antibody

Details for Product No. ABIN388868
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Antigen
Synonyms UCH-L1, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1, AW822034, C88048, R75593, UCHL-1, gad, cb358, wu:fc55h08, UCHL1, park5, pgp9.5, uch-l1, MGC132191, uchl1
Epitope
N-Term, AA 16-46
(23), (10), (9), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(200), (70), (67), (25), (20), (13), (5), (4), (2), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(113), (78), (14), (12), (7), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(184), (79), (70), (50), (25), (20), (19), (10), (6), (3), (2), (1)
Pubmed 2 references available
Catalog no. ABIN388868
Quantity 400 µL
Price
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Immunogen This UCHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 AA from the N-terminal region of human UCHL1.
Clone RB04183
Isotype Ig
Specificity This PGP9.5 (UCHL1/PARK5) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24~54 amino acids from the N-terminal region of human UCHL1.
Predicted Reactivity Cow (Bovine),Pig (Porcine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PGP9.5 (UCHL1/PARK5)
Background UCHL1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (Doran et al., 1983 [PubMed 6343558]).
Synonyms: Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCH-L1, Ubiquitin thiolesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5
Pathways: Parkinson's disease
Molecular Weight 24824 Da
Gene ID 7345
UniProt P09936
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term), (AA 16-46) antibody Western blot analysis of UCHL1-V31 (ABIN388868) in CEM, Jurkat, Y79 cell line and mouse brain tissue lysates (35 µg/lane). UCHL1 (arrow) was detected using the purified polyclonal antibody.
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term), (AA 16-46) antibody (2) Western blot analysis of UCHL1 (arrow) using rabbit polyclonal UCHL1-V31 (ABIN388868). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the UCHL1 gene (Lane 2) (Origene Technologies).
anti-Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1) (N-Term), (AA 16-46) antibody (3) Formalin-fixed and paraffin-embedded human brain tissue reacted with UCHL1 (Park5) antibody (N-term) (ABIN388868), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Saigoh, Wang, Suh et al.: "Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice." in: Nature genetics, Vol. 23, Issue 1, pp. 47-51, 1999 (PubMed).

Caballero, Resto, Patturajan et al.: "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)." in: Oncogene, Vol. 21, Issue 19, pp. 3003-10, 2002 (PubMed).

Hosts (113), (78), (14), (12), (7), (1)
Reactivities (200), (70), (67), (25), (20), (13), (5), (4), (2), (2), (2), (1), (1), (1), (1)
Applications (184), (79), (70), (50), (25), (20), (19), (10), (6), (3), (2), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (23), (10), (9), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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