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Details for Product No. ABIN388890

Ubiquitin Specific Peptidase 8 (USP8) (N-Term), (AA 1-30) antibody

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Antigen
Synonyms HumORF8, UBPY, AI574262, AW557536, Ubpy, mKIAA0055
Epitope
»Alternatives N-Term, AA 1-30
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN388890
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This USP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human USP8.
Clone RB4284
Isotype Ig
Specificity This USP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8~38 amino acids from the N-terminal region of human USP8.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name USP8
Background USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structur/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.
Molecular Weight 127523 DA
Gene ID 9101
UniProt UBP8_HUMAN
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Naviglio, Mattecucci, Matoskova et al.: "UBPY: a growth-regulated human ubiquitin isopeptidase." in: The EMBO journal, Vol. 17, Issue 12, pp. 3241-50, 1998 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Alternatives for antigen "Ubiquitin Specific Peptidase 8 (USP8)", type "Antibodies"
Hosts (20), (3), (1)
Reactivities (24)
Applications (24), (6), (5), (4)
Epitopes (13), (5), (4), (3)
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