Ubiquilin 1 antibody (N-Term)

Catalog No. ABIN388971

Product Details anti-Ubiquilin 1 Antibody

Target: Ubiquilin 1 (UBQLN1)

Binding Specificity: AA 19-49, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ubiquilin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Ubiquilin1 (PLIC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-49 amino acids from the N-terminal region of human Ubiquilin1 (PLIC1).

Clone: RB4615

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Ubiquilin 1 antibody (ABIN388971)

Sick, Boukhari, Deramaudt, Rondé, Bucher, André, Gies, Takeda: "Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway." in: Glia, Vol. 59, Issue 2, pp. 308-19, (2010) (PubMed).

Target Details for Ubiquilin 1

Target: Ubiquilin 1 (UBQLN1)

Alternative Name: Ubiquilin1 (PLIC1) (UBQLN1 Products)

Synonyms: UBQLN1 antibody, DA41 antibody, DSK2 antibody, PLIC-1 antibody, UBQN antibody, XDRP1 antibody, 1110046H03Rik antibody, 1810030E05Rik antibody, AU019746 antibody, C77538 antibody, D13Ertd372e antibody, Da41 antibody, Dsk2 antibody, Plic-1 antibody, Plic1 antibody, Xdrp1 antibody, ubiquilin 1 antibody, UBQLN1 antibody, Ubqln1 antibody

Background: PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.

Molecular Weight: 62519

Gene ID: 29979

NCBI Accession: NP_038466, NP_444295

UniProt: Q9UMX0