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CHEK1 antibody (AA 258-287)
CHEK1
Reactivity: Human, Mouse
WB
Host: Rabbit
Polyclonal
RB7840
unconjugated
Product Details anti-CHEK1 Antibody
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Target
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CHEK1
(Checkpoint Kinase 1 (CHEK1))
Binding Specificity
All epitopes for CHEK1 antibodies
AA 258-287
Reactivity
All reactivities for CHEK1 antibodies
Human, Mouse
Host
All hosts for CHEK1 antibodies
Rabbit
Clonality
All clonalities for CHEK1 antibodies
Polyclonal
Conjugate
All conjugates for CHEK1 antibodies
This CHEK1 antibody is un-conjugated
Application
All applications for CHEK1 antibodies
Western Blotting (WB)
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CHK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from human CHK1.
Clone
RB7840
Isotype
Ig Fraction
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Discover our top product CHEK1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date
6 months
Target Details for CHEK1
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Target
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Alternative Name
CHK1 (CHEK1 Products )
Synonyms
An08g10320 antibody, AO090003000441 antibody, CHK1 antibody, chk1 antibody, C85740 antibody, Chk1 antibody, rad27 antibody, id:ibd2720 antibody, zgc:56093 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, serine/threonine-protein kinase chk1 antibody, serine/threonine-protein kinase Chk1 antibody, CAMK/CAMKL/CHK1 protein kinase Chk1 antibody, checkpoint kinase 1 S homeolog antibody, CHEK1 antibody, ANI_1_2436074 antibody, AOR_1_768154 antibody, PTRG_04183 antibody, SJAG_01680 antibody, PAAG_04978 antibody, MCYG_03290 antibody, VDBG_03742 antibody, chek1.S antibody, Chek1 antibody, chek1 antibody
Background
HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.
Molecular Weight
54434
NCBI Accession
NP_001107593 , NP_001107594 , NP_001231775 , NP_001265
UniProt
O14757
Pathways
p53 Signaling , Apoptosis , Cell Division Cycle , DNA Damage Repair
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