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Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) (AA 1-30), (N-Term) antibody

Details for Product No. ABIN389018, Supplier: Login to see
Antigen
  • 4930406E12Rik
  • AU016030
  • AW209092
  • fb33h10
  • im:6912200
  • wu:fb33h10
  • zgc:101044
Epitope
AA 1-30, N-Term
22
15
5
4
4
2
2
1
1
Reactivity
Human, Mouse (Murine)
55
20
16
2
1
1
Host
Rabbit
50
8
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
43
26
11
9
8
7
3
2
2
1
Supplier
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Immunogen This GGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human GGA1.
Clone RB4932
Isotype Ig
Specificity This GGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human GGA1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GGA1 (GGA1 Antibody Abstract)
Background GGA1 is a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins.
Synonyms: ADP-ribosylation factor binding protein GGA1, Golgi-localized, gamma ear-containing, ARF-binding protein 1, Gamma-adaptin related protein 1
Molecular Weight 70384 DA
Gene ID 26088
UniProt Q9UJY5
Research Area Protein Modifications, Cell Structure
Pathways
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) (AA 1-30), (N-Term) antibody (ABIN389018) The anti-GGA1 Pab (ABIN389018) is used in Western blot to detect GGA1 in mouse kidney...
Immunohistochemistry (IHC) image for anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 1 (GGA1) (AA 1-30), (N-Term) antibody (ABIN389018) A, N2a cells cotransfected with APP770 �V5 and GGA1 �myc or empty vector were immunos...
Product cited in: von Arnim, Spoelgen, Peltan et al.: "GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 26, Issue 39, pp. 9913-22, 2006 (PubMed).

Background publications Zhai, He, Liu et al.: "The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle." in: Biochemistry, Vol. 42, Issue 47, pp. 13901-8, 2003 (PubMed).

Zhu, Zhai, He et al.: "Crystal structure of the human GGA1 GAT domain." in: Biochemistry, Vol. 42, Issue 21, pp. 6392-9, 2003 (PubMed).

Shiba, Takatsu, Nogi et al.: "Structural basis for recognition of acidic-cluster dileucine sequence by GGA1." in: Nature, Vol. 415, Issue 6874, pp. 937-41, 2002 (PubMed).