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GPLD1 antibody (C-Term)

GPLD1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB04854 unconjugated
Catalog No. ABIN389063
  • Target See all GPLD1 Antibodies
    GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))
    Binding Specificity
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 679-709, C-Term
    Reactivity
    • 61
    • 19
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 58
    • 3
    Rabbit
    Clonality
    • 60
    • 1
    Polyclonal
    Conjugate
    • 19
    • 7
    • 7
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GPLD1 antibody is un-conjugated
    Application
    • 56
    • 34
    • 13
    • 13
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This GPLD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 679-709 amino acids from the C-terminal region of human GPLD1.
    Clone
    RB04854
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GPLD1 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    GPLD1 (Glycosylphosphatidylinositol Specific phospholipase D1 (GPLD1))
    Alternative Name
    GPLD1 (GPLD1 Products)
    Synonyms
    GPIPLD antibody, GPIPLDM antibody, PIGPLD antibody, PIGPLD1 antibody, 6330541J12Rik antibody, AW546131 antibody, glycosylphosphatidylinositol specific phospholipase D1 antibody, glycosylphosphatidylinositol specific phospholipase d1 antibody, GPLD1 antibody, gpld1 antibody, Micau_0957 antibody, ML5_1205 antibody, VAB18032_09490 antibody, Gpld1 antibody
    Background
    GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
    Molecular Weight
    92336
    Gene ID
    2822
    NCBI Accession
    NP_001494
    UniProt
    P80108
    Pathways
    Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process
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