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Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 374-403), (C-Term) antibody

Details for Product No. ABIN389194, Supplier: Login to see
Antigen
  • INDO
  • ido
  • indo
  • IDO
  • cd107b
  • IDO1
  • IDO-1
  • Ido
  • Indo
Epitope
AA 374-403, C-Term
18
13
11
9
7
5
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Human
166
44
30
6
3
1
1
1
1
1
Host
Rabbit
95
65
19
3
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
5
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
125
73
45
34
26
17
13
11
6
5
4
4
4
1
1
1
1
Supplier
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Immunogen This INDO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374-403 AA from the C-terminal region of human INDO.
Clone RB15061
Isotype Ig
Specificity This INDO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 374~403 amino acids from the C-terminal region of human INDO.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name INDO (IDO1 Antibody Abstract)
Background Gamma-interferon (IFNG, MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO, EC 1.13.11.52). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine.[supplied by OMIM]
Synonyms: Indoleamine 2,3-dioxygenase, IDO, EC 1.13.11.52, Indoleamine-pyrrole 2,3-dioxygenase, INDO, IDO
Molecular Weight 45326 DA
Gene ID 3620
UniProt P14902
Research Area Stem Cells, Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 374-403), (C-Term) antibody (ABIN389194) Western blot analysis of anti-INDO Antibody (C-term) (ABIN389194) in 293 cell line ly...
Immunohistochemistry (IHC) image for anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) (AA 374-403), (C-Term) antibody (ABIN389194) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with INDO an...
Background publications Maghzal, Thomas, Hunt et al.: "Cytochrome b5, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12014-25, 2008 (PubMed).

Scheler, Wenzel, Tüting et al.: "Indoleamine 2,3-dioxygenase (IDO): the antagonist of type I interferon-driven skin inflammation?" in: The American journal of pathology, Vol. 171, Issue 6, pp. 1936-43, 2007 (PubMed).