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ITGA5 antibody (Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide)) (AA 796-824)

Details for Product anti-ITGA5 Antibody No. ABIN389403, Supplier: Log in to see
Antigen
  • CD49e
  • Cd49e
  • FNRA
  • Fnra
  • ITGA5
  • Itga5_retired
  • VLA5
  • VLA5A
Epitope
AA 796-824, C-Term
29
16
15
15
13
10
5
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
189
159
42
3
3
3
3
1
Host
Rabbit
116
81
79
31
4
Clonality (Clone)
Polyclonal ()
Conjugate
This ITGA5 antibody is un-conjugated
38
25
20
6
5
5
5
4
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
198
120
70
70
45
41
21
17
16
11
6
6
3
2
2
2
2
1
1
1
Supplier
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Immunogen This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-824 AA from the C-terminal region of human CD49e.
Clone RB18004
Isotype Ig
Specificity This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 803~832 amino acids from the C-terminal region of human CD49e.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CD49e (ITGA5 Antibody Abstract)
Background CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein is the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Synonyms: Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49 antigen-like family member E, CD_antigen=CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5
Molecular Weight 114536 DA
Gene ID 3678
UniProt P08648
Research Area Stem Cells
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ITGA5 antibody (Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide)) (AA 796-824) (ABIN389403) Western blot analysis of CD49e antibody (C-term) (ABIN389403) in mouse bladder tissue...
Immunohistochemistry (IHC) image for anti-ITGA5 antibody (Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide)) (AA 796-824) (ABIN389403) Flow cytometric analysis of HepG2 cells using CD49e Antibody (C-term)(bottom histogra...
Background publications Boehmler, Drost, Jaggy, Seitz, Wiesner, Denzlinger, Kanz, Möhle: "The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 6789-98, 2009

Okazaki, Ni, Ayeni, Baluk, Yao, Vossmeyer, Zischinsky, Zahn, Knolle, Christner, McDonald: "alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2378-87, 2009

Schornberg, Shoemaker, Dube, Abshire, Delos, Bouton, White: "Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 8003-8, 2009