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AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1) (pSer129)

Details for Product anti-AKT1 Antibody No. ABIN389509, Supplier: Log in to see
Antigen
  • Akt
  • akt
  • AKT
  • akt-1
  • Akt/PKB
  • AKT/PKB
  • AKT1
  • akt1
  • Akt1
  • ATAKT1
  • CG4006
  • CWS6
  • D-Akt
  • dAKT
  • dakt
  • dAkt
  • Dakt
  • DAkt
  • dAKT/dPKB
  • dAkt/PKB
  • dakt1
  • dAkt1
  • dAKT1
  • DAkt1
  • DAKT1
  • Dakt1
  • DAKT1/PKB
  • Dmel\\CG4006
  • Dpkb
  • DPKB
  • dPKB
  • DRAC-PK
  • DRAC-PK66
  • DRAC-PK85
  • F18A8.2
  • F18A8_2
  • K+ transporter 1
  • l(3)04226
  • l(3)89Bq
  • p-Akt
  • pAkt
  • pkb
  • PKB
  • PKB-ALPHA
  • PKB/Akt
  • PKB/AKT
  • PKB/dAKT
  • PKBalpha
  • POTASSIUM TRANSPORTER
  • PRKBA
  • Rac
  • RAC
  • RAC-ALPHA
  • RacPK
  • v-akt
  • v-akt1
  • xAct
Alternatives
anti-Human AKT antibody for Western Blotting
Epitope
pSer129
187
136
90
87
54
38
38
37
25
25
21
21
21
18
16
15
15
15
14
13
11
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8
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5
5
5
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4
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4
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4
4
4
4
3
3
3
3
3
3
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2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1160
542
410
44
41
37
34
32
20
18
11
6
5
4
2
2
2
1
1
Host
Rabbit
892
311
14
4
1
Clonality (Clone)
Polyclonal ()
Conjugate
This AKT antibody is un-conjugated
45
39
35
34
26
25
10
10
5
5
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Application
Dot Blot (DB)
975
554
446
223
142
120
117
70
63
36
24
11
11
5
3
3
3
3
2
1
1
1
1
1
1
Supplier
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Immunogen This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S129 of human AKT1.
Clone RB25385
Isotype Ig
Specificity This Phospho-AKT1-S129 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S129 of human AKT1.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKT1 (AKT1 Antibody Abstract)
Background The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Synonyms: RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, PKB, RAC,
Molecular Weight 55686 DA
Gene ID 207
UniProt P31749
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure
Pathways PI3K-Akt Signaling, RTK Signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1) (pSer129) (ABIN389509) Dot blot analysis of anti-AKT1-pS129 Phospho-specific Pab (ABIN389509) on nitrocellul...
Background publications DeBusk, Hallahan, Lin: "Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway." in: Experimental cell research, Vol. 298, Issue 1, pp. 167-77, 2004 (PubMed).

Kyoung Pyo, Lovati, Pasinetti, Ksiezak-Reding: "Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT." in: Neuroscience, Vol. 127, Issue 3, pp. 649-58, 2004 (PubMed).

LeVea, Reeder, Mooney: "EGF-dependent cell cycle progression is controlled by density-dependent regulation of Akt activation." in: Experimental cell research, Vol. 297, Issue 1, pp. 272-84, 2004 (PubMed).

Bommhardt, Chang, Swanson, Wagner, Tinsley, Karl, Hotchkiss: "Akt decreases lymphocyte apoptosis and improves survival in sepsis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7583-91, 2004 (PubMed).

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