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beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody

Details for Product No. ABIN389517, Supplier: Log in to see
Antigen
  • ASP2
  • Bace
  • BACE
  • BACE1
  • BACE2
  • bace2
  • C76936
  • HSPC104
  • MGC68482
  • MGC68881
  • MGC145931
  • zgc:77409
Epitope
pSer498
45
29
24
13
12
10
8
5
5
5
5
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
228
121
84
21
8
5
3
3
3
2
2
2
2
2
2
1
1
Host
Rabbit
190
46
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
8
7
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
154
84
57
45
22
20
20
14
11
5
3
2
2
2
2
Supplier
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Immunogen This BACE Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.
Clone RB7137
Isotype Ig
Specificity This Phospho-BACE-S498 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BACE (BACE Antibody Abstract)
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Synonyms: Beta-secretase 1 [Precursor], Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2, BACE1, BACE,
Molecular Weight 55764 DA
Gene ID 23621
UniProt P56817
Research Area Protein Modifications, Cell Structure, Phospho-specific antibodies, Neurology
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody (ABIN389517) The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho...
Immunohistochemistry (IHC) image for anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody (ABIN389517) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).

He, Li, Chang, Tang: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).

Huang, Chang, Koelsch, Turner, Lupu, Tang: "Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37886-94, 2004 (PubMed).

Chiocco, Kulnane, Younkin, Younkin, Evin, Lamb: "Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52535-42, 2004 (PubMed).