beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody

Details for Product No. ABIN389517
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Antigen
Synonyms BACE1, MGC145931, bace2, MGC68881, MGC68482, BACE2, C76936, Bace, ASP2, BACE, HSPC104, zgc:77409
Epitope
pSer498
(21), (18), (17), (10), (8), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(144), (70), (48), (25), (24), (24), (19), (12), (1)
Host
Rabbit
(135), (8), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(92), (58), (40), (27), (20), (15), (7), (6), (5), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN389517
291.50 $
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Immunogen This BACE Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.
Clone RB7137
Isotype Ig
Specificity This Phospho-BACE-S498 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BACE
Background Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Synonyms: Beta-secretase 1 [Precursor], Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2, BACE1, BACE,
Molecular Weight 55764 DA
Gene ID 23621
UniProt P56817
Research Area Protein Modifications, Cell Structure, Phospho-specific antibodies, Neurology
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.36 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody The anti-Phospho-BACE-S498 Pab (ABIN389517) is used in Western blot to detect Phospho-BACE-S498 in mouse brain tissue lysate
anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Huang, Chang, Koelsch et al.: "Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37886-94, 2004 (PubMed).

Chiocco, Kulnane, Younkin et al.: "Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52535-42, 2004 (PubMed).

He, Li, Chang et al.: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).

Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).

Validation Images
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