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beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This Phospho-BACE-S498 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.|
|Description||Other names: Beta-secretase 1 [Precursor], Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2, BACE1, BACE,|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Phospho-BACE-S498 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S498 of human BACE.|
|Molecular Weight||55764 DA|
Background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
|Synonyms||ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2|
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein G affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylate|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Protein Modifications, Cell Structure, Phospho-specific antibodies, Neurology|
|Restrictions||For Research Use only|
Huang, Chang, Koelsch et al.: "Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein." in: The Journal of biological chemistry, Vol. 279, Issue 36, pp. 37886-94, 2004 (PubMed).
Chiocco, Kulnane, Younkin et al.: "Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52535-42, 2004 (PubMed).
He, Li, Chang et al.: "GGA proteins mediate the recycling pathway of memapsin 2 (BACE)." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11696-703, 2005 (PubMed).
Xie, Guo: "PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13824-32, 2005 (PubMed).