AKT3 antibody (pSer472)

Catalog No. ABIN389853

Product Details anti-AKT3 Antibody

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Binding Specificity: pSer472

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKT3 antibody is un-conjugated

Application: Dot Blot (DB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AKT3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S472 of human AKT3.

Clone: RB13331

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-AKT3 antibody (ABIN389853)

Liu, Huang, Ren, Wen, Liu, Yang, Wang, Zhu, Zeng, Feng, Zhang, Chen, Jia, Zhang, Xia, Chen: "Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-?B and PI3K/Akt3 signaling pathways." in: Scientific reports, Vol. 5, pp. 11614, (2015) (PubMed).

Yang, Xiong, Luo, Yang, Xi: "8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 37, Issue 1, pp. 361-74, (2015) (PubMed).

Li, Jia, Ren, Liu, Gong, Wang, Zhang, Zhao: "Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma." in: IUBMB life, Vol. 66, Issue 7, pp. 507-18, (2014) (PubMed).

Huang, Gonzalez, Toy, Banerjee, Kleer: "Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells." in: Cancer research, Vol. 70, Issue 8, pp. 3340-50, (2010) (PubMed).

Silva, Garvin: "Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs." in: American journal of physiology. Renal physiology, Vol. 297, Issue 3, pp. F646-52, (2009) (PubMed).

Target Details for AKT3

Target: AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3))

Alternative Name: AKT3 (AKT3 Products)

Synonyms: MPPH antibody, PKB-GAMMA antibody, PKBG antibody, PRKBG antibody, RAC-PK-gamma antibody, RAC-gamma antibody, STK-2 antibody, AI851531 antibody, D930002M15Rik antibody, Nmf350 antibody, Pkbg antibody, AKT serine/threonine kinase 3 antibody, thymoma viral proto-oncogene 3 antibody, v-akt murine thymoma viral oncogene homolog 3b antibody, AKT3 antibody, Akt3 antibody, akt3b antibody

Background: AKT3 is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1).

Molecular Weight: 55775

Gene ID: 10000

NCBI Accession: NP_001193658, NP_005456, NP_859029

UniProt: Q9Y243

Pathways: PI3K-Akt Signaling, RTK Signaling, TLR Signaling, Hepatitis C, VEGF Signaling