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Cyclin-Dependent Kinase 2 (CDK2) (pThr41) antibody

Antigen

Cyclin-Dependent Kinase 2 (CDK2)
Synonyms p33(CDK2), A630093N05Rik, MGC849, 1810047K05Rik, 2810452K22Rik, RGD1563395, CINP, 2810452K22RIK, MGC84068, cinp, MGC166364, zgc:56598, zgc:77684, wu:fa10c02, CDK2
Binding Site
Alternatives

pThr41
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Dot Blot (Dot), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN389884
Quantity 400 µL  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Cyclin-Dependent Kinase 2 (CDK2) (pThr41) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name Cdk2
Gene ID 1017
UniProt P24941
Immunogen This Phospho-CDK2-pT41 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Isotype Ig
Description Other names: Cell division protein kinase 2, p33 protein kinase, CDK2
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This Phospho-CDK2-pT41 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Molecular Weight 33930 DA
Comments

Background: CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Dot blot~~1:500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Cell Cycle, Phospho-specific antibodies, Cell Structure
Restrictions For Research Use only

Publications
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Product Park, Kim, Lee et al.: "Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 19592-9, 2004 (PubMed).

Kim, Park, Lee et al.: "Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin." in: Biochemical and biophysical research communications, Vol. 317, Issue 2, pp. 478-83, 2004 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Cyclin-Dependent Kinase 2 (CDK2)", type "Antibodies"
Hosts Rabbit (126), Mouse (35)
Reactivities Human (149), Mouse (Murine) (72), Rat (Rattus) (70), Cow (Bovine) (31), Horse (Equine) (28), Guinea Pig (23), Pig (Porcine) (23), Dog (Canine) (9), Chicken (3), Monkey (3), Xenopus laevis (3), Zebrafish (2), Cat (Feline) (1), Rabbit (1)
Applications Western Blotting (WB) (125), ELISA (64), Immunofluorescence (IF) (57), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43), Immunohistochemistry (IHC) (35), Immunoprecipitation (IP) (24), Flow Cytometry (FACS) (13), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Dot Blot (DB) (1), Dot Blot (Dot) (1), Fluorescence Microscopy (FM) (1), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Biotin (7), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pThr160 (15), C-Term (12), pThr14 (7), Internal Region (6), Thr160 (3), AA 287-298 (2), Thr14 (2), Center (1), Center,Arg199 (1), N-Term (1), pThr305 (1), pThr41 (1), pThr48 (1), pTyr15 (1)