Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody

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Antigen
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
Epitope
pThr202, pTyr204
114
103
30
30
28
19
18
17
15
15
15
15
15
12
9
9
9
8
7
7
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
403
313
301
57
24
15
9
8
8
8
7
6
5
5
3
3
2
2
2
1
1
1
1
Host
Rabbit
331
76
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
12
11
11
9
7
7
7
6
6
6
6
6
6
6
2
2
2
1
1
1
1
1
1
Application
Dot Blot (DB), Western Blotting (WB)
291
106
81
78
61
54
39
38
14
10
6
3
3
2
2
2
2
Options
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Immunogen This ERK1/2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T202/Y204 of human ERK1/2.
Clone RB15981
Isotype Ig
Specificity This Bi-phospho-ERK1/2-T202/Y204 antibody is generated from rabbits immunized with a KLH conjugated synthetic bisphosphopeptide incorporating amino acid residues surrounding phosphorylated T202 and Y204 of human ERK1.
Predicted Reactivity Fruit Fly (Drosophila melanogaster),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ERK1/2 (MAPK1/3 Antibody Abstract)
Background MAPK3 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets.
Synonyms: Mitogen-activated protein kinase 3, Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule-associated protein 2 kinase, MAPK3, ERK1, PRKM3
Molecular Weight 43136 DA
Gene ID 5595
UniProt P27361
Research Area Cell Signaling, Protein Modifications, Cell Cycle, Phospho-specific antibodies, Cell Structure
Application Notes DB = 1:500, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody (ABIN389990) Dot blot analysis of Bi-phospho-ERK1/2-T202/Y204 Antibody (ABIN389990) on nitrocellul...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody (ABIN389990) Western blot analysis of ERK1/2 (arrow) using rabbit polyclonal P-MAPK(T202/Y204) (AB...
Western Blotting (WB) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (pThr202), (pTyr204) antibody (ABIN389990) Western blot analysis of ERK1/2 (arrow) using rabbit polyclonal P-MAPK(T202/Y204) (AB...
Background publications Munshi, Wu, Mukhopadhyay, Ottaviano, Sassano, Koblinski, Platanias, Stack et al.: "Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth ..." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 39042-50, 2004 (PubMed).