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CDK2 antibody (Cyclin-Dependent Kinase 2) (pThr14)

Details for Product anti-CDK2 Antibody No. ABIN389996, Supplier: Log in to see
Antigen
  • MGC84068
  • cinp
  • CINP
  • p33(CDK2)
  • A630093N05Rik
  • wu:fa10c02
  • zgc:56598
  • zgc:77684
  • eg1
  • CDKN2
  • cdk2L
Alternatives
anti-Human CDK2 antibody for Western Blotting
Epitope
pThr14
51
46
24
13
9
7
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7
5
4
4
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
248
142
117
9
9
8
7
7
6
5
4
4
3
Host
Rabbit
233
42
1
Clonality (Clone)
Polyclonal ()
Conjugate
This CDK2 antibody is un-conjugated
11
8
7
4
4
4
4
3
3
3
3
3
3
3
3
Application
Dot Blot (DB)
213
103
68
44
40
34
33
30
12
10
9
8
3
2
1
1
1
1
Supplier
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Immunogen This CDK2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Clone RB7700
Isotype Ig
Specificity This Phospho-CDK2-pT14 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Predicted Reactivity Cow (Bovine),Hamster,Mouse (Murine),Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Cdk2 (CDK2 Antibody Abstract)
Background CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
Synonyms: Cell division protein kinase 2, p33 protein kinase
Molecular Weight 33930 DA
Gene ID 1017
UniProt P24941
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways PI3K-Akt Signaling, Cell Division Cycle
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Dot Blot (DB) image for anti-CDK2 antibody (Cyclin-Dependent Kinase 2) (pThr14) (ABIN389996) Dot blot analysis of anti-Phospho-CDK2-pT14 Antibody (ABIN389996) on nitrocellulose m...
Background publications Ninomiya-Tsuji, Nomoto, Yasuda et al.: "Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9006-10, 1991 (PubMed).

Elledge, Spottswood: "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1." in: The EMBO journal, Vol. 10, Issue 9, pp. 2653-9, 1991 (PubMed).

Tsai, Harlow, Meyerson: "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase." in: Nature, Vol. 353, Issue 6340, pp. 174-7, 1991 (PubMed).

Gu, Rosenblatt, Morgan: "Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15." in: The EMBO journal, Vol. 11, Issue 11, pp. 3995-4005, 1992 (PubMed).