|+1 404 474 4654|
|+1 888 205 9894 (TF)|
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6) (C-Term) antibody
|Synonyms||ABC, PRP, umat, ABC14, MTABC3, EST45597, FLJ22414, 1200005B17Rik, MGC93242, ABCB6, ABCA6, abcb6, MGC145484|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ABCB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 813~842 amino acids from the C-terminal region of human ABCB6.|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ABCB6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 813~842 amino acids from the C-terminal region of human ABCB6.|
|Molecular Weight||93885 DA|
Background: The membrane-associated protein ABCB6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Allikmets, Gerrard, Hutchinson et al.: "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database." in: Human molecular genetics, Vol. 5, Issue 10, pp. 1649-55, 1997 (PubMed).
Furuya, Bradley, Sun et al.: "Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis." in: Cancer research, Vol. 57, Issue 17, pp. 3708-16, 1997 (PubMed).
Mitsuhashi, Miki, Senbongi et al.: "MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17536-40, 2000 (PubMed).
|Hosts||Rabbit (35), Mouse (1)|
|Reactivities||Human (35), Rat (Rattus) (27), Mouse (Murine) (26), Dog (Canine) (20), Cow (Bovine) (19), Pig (Porcine) (19), Guinea Pig (18), Horse (Equine) (18), Cat (Feline) (1), Chicken (1), Rabbit (1)|
|Applications||Western Blotting (WB) (20), ELISA (18), Immunofluorescence (IF) (17), Immunohistochemistry (IHC) (5), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 440-455 (2), AA 827-842 (1), C-Term (1), Center (1), Internal Region (1)|