Caudal Type Homeobox 2 (CDX2) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN390076
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Antigen
Synonyms CDX2, MGC130987, cdx3-like, CDX-3, CDX3, CDX-2, Cdx-2
Epitope
N-Term, AA 1-30
(28), (16), (12), (8), (8), (6), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(135), (52), (51), (17), (13), (13), (13), (3), (1), (1)
Host
Rabbit
(103), (25), (11)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(94), (62), (37), (21), (15), (11), (10), (9), (8), (5), (2), (1), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN390076
291.50 $
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Immunogen This CDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human CDX2.
Clone RB01821
Isotype Ig
Specificity This CDX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8~38 amino acids from the N-terminal region of human CDX2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDX2
Background The caudal type homeo box transcription factors 1 (CDX1) and 2 (CDX2) are candidates for directing intestinal development, differentiation, and maintenance of the intestinal phenotype. CDX1 and CDX2 expression is widely present in the human intestinal and colonic mucosae, but not in the gastric mucosa, suggesting a possible role in the terminal differentiation of the intestine. Increased CDX2 expression is associated with chronic atrophic gastritis. Detectable expression of CDX2 precedes expression of CDX1 during the progression of intestinal metaplasia, thus expression of CDX2 may trigger the initiation and development of intestinal metaplasia. Markedly reduced or absent CDX2 expression was noted by immunohistochemistry in 13 of 15 (87%) large cell minimally differentiated carcinomas (LCMDCs), whereas only 1 of the 25 (4%) differentiated adenocarcinomas (DACs) showed reduced CDX2 expression. Thus, a significant decrease in human CDX1 and/or CDX2 expression may be associated with colorectal tumorigenesis.
Molecular Weight 33509 DA
Gene ID 1045
UniProt Q99626
Research Area Stem Cells, Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Caudal Type Homeobox 2 (CDX2) (N-Term), (AA 1-30) antibody The anti-CDX2 N-term Pab (ABIN390076) is used in Western blot to detect CDX2 in placenta tissue lysate.
anti-Caudal Type Homeobox 2 (CDX2) (N-Term), (AA 1-30) antibody (2) Western blot analysis of CDX2(arrow) using rabbit polyclonal CDX2 Antibody (N-term)(ABIN390076). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the CDX2 gene (Lane 2) (Origene Technologies).
anti-Caudal Type Homeobox 2 (CDX2) (N-Term), (AA 1-30) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Eda, Osawa, Yanaka et al.: "Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia." in: Journal of gastroenterology, Vol. 37, Issue 2, pp. 94-100, 2002 (PubMed).

Moucadel, Totaro, Dell et al.: "The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells." in: Biochemical and biophysical research communications, Vol. 297, Issue 3, pp. 607-15, 2002 (PubMed).

Yamamoto, Bai, Yuasa: "Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression." in: Biochemical and biophysical research communications, Vol. 300, Issue 4, pp. 813-8, 2003 (PubMed).

Bai, Miyake, Iwai et al.: "CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene." in: Oncogene, Vol. 22, Issue 39, pp. 7942-9, 2003 (PubMed).

Phillips, Frierson, Moskaluk: "Cdx2 as a marker of epithelial intestinal differentiation in the esophagus." in: The American journal of surgical pathology, Vol. 27, Issue 11, pp. 1442-7, 2003 (PubMed).

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