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Details for Product No. ABIN390100

Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term), (AA 1531-1560) antibody

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Antigen
Synonyms ADCAD2, C030016K15Rik, Cd, Gw, lrp6-A, Xlrp6, adcad2, lrp6, LRP6
Epitope
»Alternatives C-Term, AA 1531-1560
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN390100
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 AA from the C-terminal region of human LRP6.
Clone RB01837
Isotype Ig
Specificity This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1538~1568 amino acids from the C-terminal region of human LRP6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LRP6
Background LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Synonyms: LDL receptor-related protein 6
Molecular Weight 180442 DA
Gene ID 4040
UniProt O75581
Research Area Stem Cells, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Brown, Twells, Hey et al.: "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family." in: Biochemical and biophysical research communications, Vol. 248, Issue 3, pp. 879-88, 1998 (PubMed).

Alternatives for antigen "Low Density Lipoprotein Receptor-Related Protein 6 (LRP6)", type "Antibodies"
Hosts (67), (7), (1)
Reactivities (71), (42), (42), (41), (41), (30), (12), (12), (1)
Applications (30), (28), (28), (23), (15), (5), (3), (2), (1), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1)
Epitopes (14), (13), (5), (4), (3), (1), (1)
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