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Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term), (AA 1531-1560) antibody

Details for Product No. ABIN390100
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Antigen
Synonyms lrp6-A, Xlrp6, adcad2, lrp6, LRP6, ADCAD2, C030016K15Rik, Cd, Gw
Epitope
C-Term, AA 1531-1560
(13), (13), (11), (4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(74), (43), (42), (41), (41), (31), (12), (12), (1)
Host
Rabbit
(70), (5), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(36), (34), (21), (20), (13), (3), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 µL
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Catalog No. ABIN390100
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Immunogen This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1560 AA from the C-terminal region of human LRP6.
Clone RB01837
Isotype Ig
Specificity This LRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1538~1568 amino acids from the C-terminal region of human LRP6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LRP6
Background LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Synonyms: LDL receptor-related protein 6
Molecular Weight 180442 DA
Gene ID 4040
UniProt O75581
Research Area Stem Cells, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term), (AA 1531-1560) antibody Western blot analysis of LRP6 (arrow) using rabbit polyclonal LRP6 Antibody (C-term T1546) (ABIN390100). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the LRP6 gene (Lane 2) (Origene Technologies).
anti-Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) (C-Term), (AA 1531-1560) antibody (2) Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with LRP6 Antibody (C-term T1546)(ABIN390100), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Brown, Twells, Hey et al.: "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family." in: Biochemical and biophysical research communications, Vol. 248, Issue 3, pp. 879-88, 1998 (PubMed).

Validation Images
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