Melanoma Antigen Family A, 3 (MAGEA3) (AA 283-314), (C-Term) antibody

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Synonyms Mage-a3, MAGEA3, CT1.3, HIP8, HYPD, MAGE3, MAGEA6
AA 283-314, C-Term
(16), (12), (7), (5), (4), (4), (3), (2), (2), (1), (1), (1)
(92), (2), (2)
(57), (35)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (2), (2), (2)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(66), (28), (26), (19), (16), (16), (8), (3), (2), (1)
Pubmed 7 references available
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-314 AA from the C-terminal region of human MAGEA3.
Clone RB2084
Isotype Ig
Specificity This MAGEA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285~314 amino acids from the C-terminal region of human MAGEA3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MAGEA3 (MAGEA3 Antibody Abstract)
Background MAGEA3 is a member of the MAGEA gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 80% sequence identity between each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are expressed at a high level in a number of tumors of various histologic types, and are silent in normal tissues with the exception of testis and placenta. The MAGEA genes are clustered on chromosome Xq28. They may be implicated in some hereditary disorders, such as dyskeratosis congenita.
Synonyms: Melanoma-associated antigen 3, MAGE-3 antigen, Antigen MZ2-D, MAGE3
Molecular Weight 34747 DA
Gene ID 4102
UniProt P43357
Research Area Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Melanoma Antigen Family A, 3 (MAGEA3) (AA 283-314), (C-Term) antibody (ABIN390107) The anti-MAGEA3 C-term Antibody (ABIN390107) is used in Western blot to detect MAGEA3...
Flow Cytometry (FACS) image for anti-Melanoma Antigen Family A, 3 (MAGEA3) (AA 283-314), (C-Term) antibody (ABIN390107) hMAGEA3-H298 Antibody (ABIN390107) flow cytometric analysis of Jurkat cells (right hi...
Immunohistochemistry (IHC) image for anti-Melanoma Antigen Family A, 3 (MAGEA3) (AA 283-314), (C-Term) antibody (ABIN390107) MAGEA3 Antibody (C-term) (ABIN390107)immunohistochemistry analysis in formalin fixed ...
Product cited in: Curioni-Fontecedro, Knights, Tinguely et al.: "MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma." in: Leukemia, Vol. 22, Issue 8, pp. 1646-8, 2008 (PubMed).

Dubovsky, Albertini, McNeel: "MAD-CT-2 identified as a novel melanoma cancer-testis antigen using phage immunoblot analysis." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 30, Issue 7, pp. 675-83, 2007 (PubMed).

Kondo, Zhu, Asa et al.: "The cancer/testis antigen melanoma-associated antigen-A3/A6 is a novel target of fibroblast growth factor receptor 2-IIIb through histone H3 modifications in thyroid cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 16, pp. 4713-20, 2007 (PubMed).

Background publications Guo, Wen, Huang et al.: "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR." in: Experimental and molecular pathology, Vol. 74, Issue 2, pp. 140-7, 2003 (PubMed).

Consogno, Manici, Facchinetti et al.: "Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3." in: Blood, Vol. 101, Issue 3, pp. 1038-44, 2003 (PubMed).

Rogner, Wilke, Steck et al.: "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28." in: Genomics, Vol. 29, Issue 3, pp. 725-31, 1996 (PubMed).

van der Bruggen, Traversari, Chomez et al.: "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma." in: Science (New York, N.Y.), Vol. 254, Issue 5038, pp. 1643-7, 1992 (PubMed).

Catalog No. ABIN390107
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