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Details for Product No. ABIN390123

MLL3 (C-Term), (AA 4345-4374) antibody

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Antigen
Synonyms E330008K23Rik, HALR, Mll3, mKIAA1506, MLL3
Epitope
»Alternatives C-Term, AA 4345-4374
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN390123
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This MLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4345-4374 AA from the C-terminal region of human MLL3.
Clone RB1921
Isotype Ig
Specificity This MLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3471~3501 amino acids from the C-terminal region of human MLL3.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL family, including MLL3. The MLL SET domain is a histone H3 Lys4 (K4)-specific methyltransferase whose activity is stimulated with acetylated H3 peptides. MLL3 maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia. The deduced MLL3 4,911-amino acid protein is more closely related to MLL2 than to MLL1 or MLL4. MLL3 has 6 plant homeodomain (PHD) fingers preceded by a cys-rich ZNF1 domain in its N terminus, a high mobility group (HMG) box, an ATPase alpha-beta signature, and a leucine zipper motif in its central region, and 2 C-terminal FY (phe-tyr) motifs and the SET domain preceded by a ZNF2 domain in its C terminus. The predicted protein also contains several putative nuclear localization motifs. Isoform II lacks ZNF1 and the PHD.
Synonyms: KIAA1506, Myeloid/lymphoid, Mixed-lineage leukemia protein 3 homolog, Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3, Homologous to ALR protein, KMT2C
Molecular Weight 541307 DA
Gene ID 58508
UniProt Q8NEZ4
Research Area Signaling, Protein Modifications, Cancer, Chromatin
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Alternatives for antigen "MLL3", type "Antibodies"
Hosts (7)
Reactivities (7)
Applications (5), (4)
Epitopes (3), (1), (1)
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