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FOXO4 antibody (Forkhead Box O4) (AA 44-73)

Details for Product anti-FOXO4 Antibody No. ABIN390133, Supplier: Log in to see
Antigen
  • afx
  • AFX
  • AFX1
  • Afxh
  • FOXO4
  • foxo4
  • MLLT7
  • Mllt7
  • RGD1561201
Alternatives
anti-Human FOXO4 antibody for Western Blotting
Epitope
AA 44-73, N-Term
38
35
23
19
16
10
7
6
5
5
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
241
141
99
7
5
2
1
1
1
1
1
Host
Rabbit
218
16
8
Clonality (Clone)
Polyclonal ()
Conjugate
This FOXO4 antibody is un-conjugated
6
6
6
3
3
3
3
3
3
3
3
3
3
3
3
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
181
92
78
33
33
31
21
8
5
Supplier
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Immunogen This MLLT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 AA from the N-terminal region of human MLLT7.
Clone RB2253
Isotype Ig
Specificity This MLLT7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51~81 amino acids from the N-terminal region of human MLLT7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MLLT7 (FOXO4 Antibody Abstract)
Background The MLLT7 (Mixed-lineage leukemia translocated to 7) protein is a forkhead transcription factor that activates apoptosis by inducing the BCL-6 transcriptional repressor. MLL-MLLT7 fusion protein transformw myeloid progenitors and impairs forkhead protein function. MLLT7 is a target of the phosphatidylinositol 3-kinase/PKB insulin signaling pathway and the AMP-activated protein kinase-dependent pathway.
Molecular Weight 53757 DA
Gene ID 4303
UniProt P98177
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Pathways Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FOXO4 antibody (Forkhead Box O4) (AA 44-73) (ABIN390133) MLLT7 Antibody (R59) (ABIN390133) western blot analysis in mouse heart tissue lysates...
Immunohistochemistry (IHC) image for anti-FOXO4 antibody (Forkhead Box O4) (AA 44-73) (ABIN390133) MLLT7 antibody (N-term) (ABIN390133)immunohistochemistry analysis in formalin fixed a...
Background publications Crossley: "Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1." in: Journal of leukocyte biology, Vol. 74, Issue 4, pp. 583-92, 2003 (PubMed).

Tang, Lasky: "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30125-35, 2003 (PubMed).

So, Cleary: "MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6542-52, 2002 (PubMed).

Tang, Dowbenko, Jackson, Toney, Lewin, Dent, Lasky: "The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 14255-65, 2002 (PubMed).

Kops, Medema, Glassford, Essers, Dijkers, Coffer, Lam, Burgering: "Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors." in: Molecular and cellular biology, Vol. 22, Issue 7, pp. 2025-36, 2002 (PubMed).