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Details for Product No. ABIN390138

Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (N-Term), (AA 145-174) antibody

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Antigen
Synonyms MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, MMP1, AI325305, MT-MMP-1, sabe, Mt1-mmp, mmp-x1, mt1-mmp, mtmmp1
Epitope
»Alternatives N-Term, AA 145-174
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN390138
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 AA from the N-terminal region of human MMP14.
Clone RB02027
Isotype Ig
Specificity This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MMP14
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
Synonyms: Matrix metalloproteinase-14 [Precursor], MMP-14, EC 3.4.24.80, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP-X1, MMP14
Molecular Weight 65883 DA
Gene ID 4323
UniProt NP_004986
Research Area Stem Cells, Protein Modifications, Cell Structure, Cancer
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).

Okada, Bellocq, Rouyer et al.: "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2730-4, 1995 (PubMed).

Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

Alternatives for antigen "Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14)", type "Antibodies"
Hosts (103), (23), (2), (1)
Reactivities (122), (43), (42), (19), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (93), (41), (38), (22), (22), (11), (10), (8), (8), (3), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (8), (4), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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