Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 396-425), (Center) antibody

Details for Product No. ABIN390145
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Antigen
Epitope
AA 396-425, Center
(9), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(23), (13), (7), (4), (1), (1), (1), (1)
Host
Rabbit
(31), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(29), (18), (15), (6), (5), (5), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN390145
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Immunogen This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 AA from the Central region of human MMP24.
Clone RB2041-2042
Isotype Ig
Specificity This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human MMP24.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MMP24
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).
Molecular Weight 73231 DA
Gene ID 10893
NCBI Accession NP_006681
Research Area Stem Cells, Protein Modifications, Cell Structure, Cancer
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 396-425), (Center) antibody Western blot analysis of MMP24 Antibody (Center) (ABIN390145) in HL60 cell line lysates (35 µg/lane). MMP24 (arrow) was detected using the purified polyclonal antibody.
anti-Matrix Metallopeptidase 24 (Membrane-inserted) (MMP24) (AA 396-425), (Center) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Llano, Pendás, Freije et al.: "Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors." in: Cancer research, Vol. 59, Issue 11, pp. 2570-6, 1999 (PubMed).

Nagase, Woessner: "Matrix metalloproteinases." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21491-4, 1999 (PubMed).

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