|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Matrix Metallopeptidase 26 (MMP26) (N-Term) antibody
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This MMP26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP26.|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This MMP26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP26.|
|Molecular Weight||29708 DA|
Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP26 may hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. It is also able to activates progelatinase B. MMP26 is expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Stem Cells, Protein Modifications, Cancer, Cell Structure|
|Restrictions||For Research Use only|
|MMP26-T42 (ABIN390147) western blot analysis in HL-60 cell line lysates (35ug/lane). This demonstrates the MMP26 antibody detected the MMP26 protein (arrow).|
Park, Ni, Gerkema et al.: "Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20540-4, 2000 (PubMed).
de Coignac, Elson, Delneste et al.: "Cloning of MMP-26. A novel matrilysin-like proteinase." in: European journal of biochemistry / FEBS, Vol. 267, Issue 11, pp. 3323-9, 2000 (PubMed).
Uría, López-Otín: "Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity." in: Cancer research, Vol. 60, Issue 17, pp. 4745-51, 2000 (PubMed).
|Hosts||Rabbit (25), Mouse (2)|
|Reactivities||Human (28), Rat (Rattus) (1)|
|Applications||Immunofluorescence (IF) (15), Western Blotting (WB) (12), ELISA (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (2), AA 42-56 (1), N-Term (1)|