OAS1 antibody (C-Term)

Catalog No. ABIN390164

Product Details anti-OAS1 Antibody

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Binding Specificity: AA 302-330, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This OAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human OAS1.

Clone: RB1937

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-OAS1 antibody (ABIN390164)

Gielen, Johnston, Edwards: "Azithromycin induces anti-viral responses in bronchial epithelial cells." in: The European respiratory journal, Vol. 36, Issue 3, pp. 646-54, (2010) (PubMed).

Kriegs, Bürckstümmer, Himmelsbach, Bruns, Frelin, Ahlén, Sällberg, Hildt: "The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo." in: The Journal of biological chemistry, Vol. 284, Issue 41, pp. 28343-51, (2009) (PubMed).

Wang, Ghosh, Baigude, Yang, Qiu, Xia, Zhou, Rana, Xu: "Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15845-52, (2008) (PubMed).

Han, Townsend, Jha, Paranjape, Silverman, Barton: "A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L." in: Journal of virology, Vol. 81, Issue 11, pp. 5561-72, (2007) (PubMed).

Alimirah, Chen, Davis, Choubey: "IFI16 in human prostate cancer." in: Molecular cancer research : MCR, Vol. 5, Issue 3, pp. 251-9, (2007) (PubMed).

van den Pol, Robek, Ghosh, Ozduman, Bandi, Whim, Wollmann: "Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain." in: Journal of virology, Vol. 81, Issue 1, pp. 332-48, (2006) (PubMed).

Lee, Wu, Lee, Chuang, Katakura, Liu, Chan, Tawatao, Chung, Shen, Cottam, Lai, Raz, Carson: "Activation of anti-hepatitis C virus responses via Toll-like receptor 7." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 6, pp. 1828-33, (2006) (PubMed).

Target Details for OAS1

Target: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Alternative Name: OAS1 (OAS1 Products)

Synonyms: OAS1 antibody, IFI-4 antibody, OIAS antibody, OIASI antibody, L3 antibody, Pp2a2 antibody, 2',5'-oligoadenylate synthetase 1 antibody, 2'-5'-oligoadenylate synthetase 1 antibody, 2'-5' oligoadenylate synthetase 1A antibody, protein phosphatase 2 catalytic subunit beta antibody, OAS1 antibody, Oas1a antibody, Ppp2cb antibody, Oas1 antibody

Background: OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Molecular Weight: 46029

Gene ID: 4938

NCBI Accession: NP_001027581, NP_002525, NP_058132

UniProt: P00973

Pathways: Hepatitis C